Toxicity Weighting for Human Biomonitoring Mixture Risk Assessment: A Proof of Concept.

ABSTRACT: Chemical mixture risk assessment has, in the past, primarily focused on exposures quantified in the external environment. Assessing health risks using human biomonitoring (HBM) data provides information on the internal concentration, from which a dose can be derived, of chemicals to which human populations are exposed. This study describes a proof of concept for conducting mixture risk assessment with HBM data, using the population-representative German Environmental Survey (GerES) V as a case study. We first attempted to identify groups of correlated biomarkers (also known as 'communities', reflecting co-occurrence patterns of chemicals) using a network analysis approach (n = 515 individuals) on 51 chemical substances in urine. The underlying question is whether the combined body b

SUBMITTER: Loh MM 

PROVIDER: S-EPMC10223739 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature