Challenges and Opportunities in the Oral Delivery of Recombinant Biologics.

ABSTRACT: Recombinant biological molecules are at the cutting-edge of biomedical research thanks to the significant progress made in biotechnology and a better understanding of subcellular processes implicated in several diseases. Given their ability to induce a potent response, these molecules are becoming the drugs of choice for multiple pathologies. However, unlike conventional drugs which are mostly ingested, the majority of biologics are currently administered parenterally. Therefore, to improve their limited bioavailability when delivered orally, the scientific community has devoted tremendous efforts to develop accurate cell- and tissue-based models that allow for the determination of their capacity to cross the intestinal mucosa. Furthermore, several promising approaches have been imagined t

SUBMITTER: Masloh S 

PROVIDER: S-EPMC10223909 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature