Association of a high-fat diet with I-FABP as a biomarker of intestinal barrier dysfunction driven by metabolic changes in Wistar rats.

ABSTRACT:

Background

The epithelial lining of the gut expresses intestinal fatty-acid binding proteins (I-FABPs), which increase in circulation and in plasma concentration during intestinal damage. From the perspective of obesity, the consumption of a diet rich in fat causes a disruption in the integrity of the gut barrier and an increase in its permeability.

Hypothesis

There is an association between the expression of I-FABP in the gut and various metabolic changes induced by a high-fat (HF) diet.

Methods

Wistar albino rats (n = 90) were divided into three groups (n = 30 per group), viz. One control and two HF diet groups (15 and 30%, respectively) were maintained for 6 weeks. Blood samples were thus collected to evaluate the lipid profile, blood glucose level and other bioche

SUBMITTER: Mahmood A 

PROVIDER: S-EPMC10223920 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature