Lung infection by Pseudomonas aeruginosa induces neuroinflammation and blood-brain barrier dysfunction in mice.

ABSTRACT:

Background

Severe lung infection can lead to brain dysfunction and neurobehavioral disorders. The mechanisms that regulate the lung-brain axis of inflammatory response to respiratory infection are incompletely understood. This study examined the effects of lung infection causing systemic and neuroinflammation as a potential mechanism contributing to blood-brain barrier (BBB) leakage and behavioral impairment.

Methods

Lung infection in mice was induced by instilling Pseudomonas aeruginosa (PA) intratracheally. We determined bacterial colonization in tissue, microvascular leakage, expression of cytokines and leukocyte infiltration into the brain.

Results

Lung infection caused alveolar-capillary barrier injury as indicated by leakage of plasma proteins across pulmonary m

SUBMITTER: Villalba N 

PROVIDER: S-EPMC10223932 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature