Omega-3 Fatty Acids Interact with <i>DPP10</i> Region Genotype in Association with Childhood Atopy.

ABSTRACT: Associations of omega-3 fatty acids (n-3) with allergic diseases are inconsistent, perhaps in part due to genetic variation. We sought to identify and validate genetic variants that modify associations of n-3 with childhood asthma or atopy in participants in the Vitamin D Antenatal Asthma Reduction Trial (VDAART) and the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC). Dietary n-3 was derived from food frequency questionnaires and plasma n-3 was measured via untargeted mass spectrometry in early childhood and children aged 6 years old. Interactions of genotype with n-3 in association with asthma or atopy at age 6 years were sought for six candidate genes/gene regions and genome-wide. Two SNPs in the region of DPP10 (rs958457 and

SUBMITTER: Lee-Sarwar KA 

PROVIDER: S-EPMC10223962 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature