Hybrid Membranes of the Ureasil-Polyether Containing Glucose for Future Application in Bone Regeneration.

ABSTRACT: The application of mesenchymal stem cells (MSC) in bone tissue regeneration can have unpredictable results due to the low survival of cells in the process since the lack of oxygen and nutrients promotes metabolic stress. Therefore, in this work, polymeric membranes formed by organic-inorganic hybrid materials called ureasil-polyether for modified glucose release were developed in order to overcome the problems posed by a of lack of this nutrient. Thus, membranes formed by polymeric blend of polypropylene oxide (PPO4000) and polyethylene oxide (PEO500) with 6% glucose incorporation were developed. Physical-chemical characterization techniques were performed, as well as tests that evaluated thermal properties, bioactivity, swelling, and release in SBF solution. The results of the swelling te

SUBMITTER: da Silva CG 

PROVIDER: S-EPMC10223991 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature