Uses and Challenges of Antiviral Polyclonal and Monoclonal Antibody Therapies.

ABSTRACT: Viral diseases represent a major public health concerns and ever-present risks for developing into future pandemics. Antiviral antibody therapeutics, either alone or in combination with other therapies, emerged as valuable preventative and treatment options, including during global emergencies. Here we will discuss polyclonal and monoclonal antiviral antibody therapies, focusing on the unique biochemical and physiological properties that make them well-suited as therapeutic agents. We will describe the methods of antibody characterization and potency assessment throughout development, highlighting similarities and differences between polyclonal and monoclonal products as appropriate. In addition, we will consider the benefits and challenges of antiviral antibodies when used in combination

SUBMITTER: Struble EB 

PROVIDER: S-EPMC10224075 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature