Exposure of Cryptococcus neoformans to Seven Commonly Used Agricultural Azole Fungicides Induces Resistance to Fluconazole as Well as Cross-Resistance to Voriconazole, Posaconazole, Itraconazole and Isavuconazole.

ABSTRACT:

Background

Cross-resistance to medical azoles by exposure to azole pesticides is well documented for Aspergillus family fungi but is poorly evaluated for other environmental pathogen fungi, particularly for yeasts belonging to the Cryptococcus neoformans/Cryptococcus gattii species complexes.

Methods

One thousand C. neoformans yeast were exposed to various concentrations of seven different commonly used azole pesticides. Clones surviving exposure were picked randomly, and their minimal inhibitory concentrations (MICs) of fluconazole, voriconazole, posaconazole, itraconazole and isavuconazole were assessed.

Results

Depending on the pesticide used for exposure, up to 13.3% of selected Cryptococcus colonies showed a phenotype of resista

SUBMITTER: Drakulovski P 

PROVIDER: S-EPMC10224184 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature