Ursodeoxycholic acid induces sarcopenia associated with decreased protein synthesis and autophagic flux.

ABSTRACT:

Background

Skeletal muscle generates force and movements and maintains posture. Under pathological conditions, muscle fibers suffer an imbalance in protein synthesis/degradation. This event causes muscle mass loss and decreased strength and muscle function, a syndrome known as sarcopenia. Recently, our laboratory described secondary sarcopenia in a chronic cholestatic liver disease (CCLD) mouse model. Interestingly, the administration of ursodeoxycholic acid (UDCA), a hydrophilic bile acid, is an effective therapy for cholestatic hepatic alterations. However, the effect of UDCA on skeletal muscle mass and functionality has never been evaluated, nor the possible involved mechanisms.

Methods

We assessed the ability of UDCA to generate sarcopenia in C57BL6 mice and develop a sa

SUBMITTER: Orozco-Aguilar J 

PROVIDER: S-EPMC10224307 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature