Adipsin alleviates cardiac microvascular injury in diabetic cardiomyopathy through Csk-dependent signaling mechanism.

ABSTRACT:

Background

Microvascular complications are associated with an overtly increased risk of adverse outcomes in patients with diabetes including coronary microvascular injury which manifested as disruption of adherens junctions between cardiac microvascular endothelial cells (CMECs). However, particular mechanism leading to diabetic coronary microvascular hyperpermeability remains elusive.

Methods

Experimental diabetes was induced in mice with adipose tissue-specific Adipsin overexpression (Adipsin^LSL/LSL-Cre) and their respective control (Adipsin^LSL/LSL). In addition, cultured CMECs were subjected to high glucose/palmitic acid (HG + PA) treatment to simulate diabetes for a mechanistic approach.

Results

The results showed that Adipsin overexpression

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10224320 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature