IFNγ-induction of T_H1-like regulatory T cells controls antiviral responses.

ABSTRACT: Regulatory T (T_reg) cells are an immunosuppressive population that are required to maintain peripheral tolerance and prevent tissue damage from immunopathology, via anti-inflammatory cytokines, inhibitor receptors and metabolic disruption. Here we show that T_reg cells acquire an effector-like state, yet remain stable and functional, when exposed to interferon gamma (IFNγ) during infection with lymphocytic choriomeningitis and influenza A virus. T_reg cell-restricted deletion of the IFNγ receptor (encoded by Ifngr1), but not the interleukin 12 (IL12) receptor (encoded by Il12rb2), prevented T_H1-like polarization (decreased expression of T-bet, CXC motif chemokine receptor 3 and IFNγ) and promoted T_H2-like polarization (increased expressi

SUBMITTER: Gocher-Demske AM 

PROVIDER: S-EPMC10224582 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature