Neurological-Type Wilson Disease: Epidemiology, Clinical Manifestations, Diagnosis, and Management.

ABSTRACT: Wilson disease (WD) is a complex metabolic disorder caused by disruptions to copper regulation within the body, leading to an unregulated accumulation of copper within various tissues. A less understood organ affected by the collection of copper is the brain, which further leads to the generation of oxygen-free radicals and resultant demyelination. Healthcare providers must keep the neurological form of WD in their list of differentials when patients present with diverse neurological manifestations. The initial step to diagnosis will be to distinguish the characteristic disease presentation with a thorough history and physical and neurological examination. A high clinical disease suspicion of WD should warrant further investigation by laboratory workup and imaging modalities to support the

SUBMITTER: Kipker N 

PROVIDER: S-EPMC10224700 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature