Biomarkers of hepatocellular synthesis in patients with decompensated cirrhosis.

ABSTRACT:

Background and aim

Since hepatocytes produce majority of serum proteins, patients with cirrhosis display substantial alterations in the serum proteome. The aim of the current study was to characterize these changes and to study the prognostic utility of hepatocellular proteins available in routine clinical testing.

Methods

Sera from 29 healthy controls and 43 patients with cirrhosis were subjected to untargeted proteomic analysis. Unsupervised hierarchical clustering was performed with Perseus software and R. Ingenuity pathway analysis (IPA) suggested upstream regulators that were validated in liver tissues. The behavior and prognostic usefulness of selected biomarkers was investigated in 61 controls and 285 subjects with decompensated cirrhosis.

Results

Proteomics un

SUBMITTER: Gurbuz B 

PROVIDER: S-EPMC10224844 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature