Genetic landscape and immune mechanism of monocytes associated with the progression of acute-on-chronic liver failure.

ABSTRACT:

Objective

Acute-on-chronic liver failure (ACLF) has a high prevalence and short-term mortality. Monocytes play an important role in the development of ACLF. However, the monocyte subpopulations with unique features and functions in ACLF and associated with disease progression remain poorly understood. We investigated the specific monocyte subpopulations associated with ACLF progression and their roles in inflammatory responses using the single-cell RNA sequencing (scRNA-seq).

Methods

We performed scRNA-seq on 17,310 circulating monocytes from healthy controls and ACLF patients and genetically defined their subpopulations to characterize specific monocyte subpopulations associated with ACLF progression.

Results

Five monocyte subpopulations were obtained, including pro-

SUBMITTER: Yao J 

PROVIDER: S-EPMC10224851 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature