Trends in the incidence of major birth defects after assisted reproductive technologies in Lombardy Region, Northern Italy.

ABSTRACT:

Purpose

The incidence of birth defects is increased in children born after assisted reproductive technologies (ART). However, changes in ART over time could influence this incidence. To investigate this issue, we present the frequency and trends of birth defects in ART and natural pregnancies in Lombardy, Northern Italy, during the period 2014-2020.

Methods

This is a population-based study using automated system of healthcare utilization (HCU) databases. ART pregnancies included only those obtained with conventional IVF or ICSI. After identifying the total number of deliveries, the rate of newborns with birth defects was compared between natural and ART pregnancies. A logistic regression model was used to calculate the adjusted odd ratio (OR). Analyses were repeated for ever

SUBMITTER: Galati G 

PROVIDER: S-EPMC10224879 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature