Validation of a multiple marker test for early pregnancy outcome prediction.

ABSTRACT:

Purpose

To validate the use of a multiple biomarker test panel for predicting first trimester pregnancy outcome in a multi-center cohort.

Methods

A case-control study of women presenting with pain and bleeding in early pregnancy at 5-10 weeks gestational age was performed at three academic centers. Sera from women with ectopic pregnancy (EP), viable intrauterine pregnancy (IUP), and miscarriage (SAB) were analyzed via immunoassay for Activin A (AA), Progesterone (P4), A Disintegrin And Metalloprotease-12 (ADAM12), pregnancy-associated plasma protein A (PAPP-A), glycodelin (Glyc), and human chorionic gonadotropin (hCG). Biomarkers were assessed for reproducibility using medians, ranges, standard deviations, and area under receiver-operating characteristic curve (AUC) and accu

SUBMITTER: Bollig KJ 

PROVIDER: S-EPMC10224881 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature