Double strand DNA breaks in sperm: the bad guy in the crowd.

ABSTRACT:

Purpose

The main objective of this opinion paper was to bring to light and enhance our understanding of the amount of double-strand DNA breaks in sperm and whether there is a threshold of no return when considering repair by the oocyte/embryo.

Methods

A brief review of literature related to the theories proposed for the appearance of double-strand breaks in human spermatozoa. Further commentary regarding their detection, how oocytes or embryos may deal with them, and what are the consequences if they are not repaired. Finally, a strategy for dealing with patients who have higher levels of double-strand DNA breaks in sperm is proposed by reviewing and presenting data using testicular extracted sperm.

Results

We propose a theory that a threshold may exist in the oocyte

SUBMITTER: Alvarez JG 

PROVIDER: S-EPMC10224897 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature