Extracting functionally accurate context-specific models of Atlantic salmon metabolism.

ABSTRACT: Constraint-based models (CBMs) are used to study metabolic network structure and function in organisms ranging from microbes to multicellular eukaryotes. Published CBMs are usually generic rather than context-specific, meaning that they do not capture differences in reaction activities, which, in turn, determine metabolic capabilities, between cell types, tissues, environments, or other conditions. Only a subset of a CBM's metabolic reactions and capabilities are likely to be active in any given context, and several methods have therefore been developed to extract context-specific models from generic CBMs through integration of omics data. We tested the ability of six model extraction methods (MEMs) to create functionally accurate context-specific models of Atlantic salmon using a generic

SUBMITTER: Molversmyr H 

PROVIDER: S-EPMC10224981 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature