Photoinhibiting via simultaneous photoabsorption and free-radical reaction for high-fidelity light-based bioprinting.

ABSTRACT: Light-based 3D bioprinting is now employed widely to fabricate geometrically complex constructs for various biomedical applications. However, the inherent light scattering defect creates significant challenges in patterning dilute hydrogels to form high-fidelity structures with fine-scale features. Herein, we introduce a photoinhibiting approach that can effectively suppress the light scattering effect via a mechanism of simultaneous photoabsorption and free-radical reaction. This biocompatible approach significantly improves the printing resolution (~1.2 - ~2.1 pixels depending on swelling) and shape fidelity (geometric error less than 5%), while minimising the costly trial-and-error procedures. The capability in patterning 3D complex constructs using different hydrogels is demonstrated b

SUBMITTER: He N 

PROVIDER: S-EPMC10224992 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature