Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces.

ABSTRACT: Emerging studies indicate that cooperation between neurons and immune cells regulates antimicrobial immunity, inflammation and tissue homeostasis. For example, a neuronal rheostat provides excitatory or inhibitory signals that control the functions of tissue-resident group 2 innate lymphoid cells (ILC2s) at mucosal barrier surfaces^1-4. ILC2s express NMUR1, a receptor for neuromedin U (NMU), which is a prominent cholinergic neuropeptide that promotes ILC2 responses^5-7. However, many functions of ILC2s are shared with adaptive lymphocytes, including the production of type 2 cytokines^8,9 and the release of tissue-protective amphiregulin (AREG)^10-12. Consequently, there is controversy regarding whether innate lymphoid cells and adaptive lymphocytes p

SUBMITTER: Tsou AM 

PROVIDER: S-EPMC10225046 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature