Transcriptional patterns of sexual dimorphism and in host developmental programs in the model parasitic nematode Heligmosomoides bakeri.

ABSTRACT:

Background

Heligmosomoides bakeri (often mistaken for Heligmosomoides polygyrus) is a promising model for parasitic nematodes with the key advantage of being amenable to study and manipulation within a controlled laboratory environment. While draft genome sequences are available for this worm, which allow for comparative genomic analyses between nematodes, there is a notable lack of information on its gene expression.

Methods

We generated biologically replicated RNA-seq datasets from samples taken throughout the parasitic life of H. bakeri. RNA from tissue-dwelling and lumen-dwelling worms, collected under a dissection microscope, was sequenced on an Illumina platform.

Results

We find extensive transcriptional sexual dimorphism throughout the fourth larval and adult s

SUBMITTER: Pollo SMJ 

PROVIDER: S-EPMC10225086 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature