Gut microbiota and risk of five common cancers: A univariable and multivariable Mendelian randomization study.

ABSTRACT:

Background

Previous studies have linked gut microbiota with cancer etiology, but the associations for specific gut microbiota are causal or owing to bias remain to be elucidated.

Methods

We performed a two-sample Mendelian randomization (MR) analysis to assess the causal effect of gut microbiota on cancer risk. Five common cancers, including breast, endometrial, lung, ovarian, and prostate cancer as well as their subtypes (sample sizes ranging from 27,209 to 228,951) were included as the outcomes. Genetic information for gut microbiota was obtained from a genome-wide association study (GWAS) comprising 18,340 participants. In univariable MR (UVMR) analysis, the inverse variance weighted (IVW) method was conducted as the primary method, with the robust adjusted profile scores

SUBMITTER: Wei Z 

PROVIDER: S-EPMC10225193 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature