Ribosomal protein L32 enhances hepatocellular carcinoma progression.

ABSTRACT:

Purpose

The underlying mechanisms of hepatocellular carcinoma (HCC) have not been fully investigated, and effective biomarkers for HCC are still needed to be explored. Therefore, our study sought to thoroughly examine the clinical significance and biological functions of the ribosomal protein L32 (RPL32) in HCC by coupling bioinformatic methods with experimental analysis.

Methods

To determine the clinical significance of RPL32, bioinformatic analyses were performed to examine RPL32 expression in HCC patient samples and to correlate RPL32 expression and HCC patient survival rates, genetic alterations, and immune cell infiltration. Cell counting kit-8 assays, colony formation, flow cytometry, and transwell assays were performed to examine the effects of RPL32 on HCC cell proli

SUBMITTER: Hou G 

PROVIDER: S-EPMC10225200 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature