The differential effects of sarcopenia and cachexia on overall survival for pancreatic ductal adenocarcinoma patients following pancreatectomy: A retrospective study based on a large population.

ABSTRACT:

Objectives

Both cachexia and sarcopenia have been considered adverse predictors for prognosis in patients with pancreatic cancer; although sarcopenia and cachexia share some similarities, they are still defined as distinct nutritional conditions. We aimed to explore the differential impacts of sarcopenia and cachexia on prognosis for pancreatic ductal adenocarcinoma (PDAC) patients following radical excision.

Methods

From January 2015 to May 2022, 614 patients undergoing surgery for PDAC were retrospectively included. Sarcopenia was defined as the L3 total skeletal muscle index below 52.4 cm² /m² (men) and 38.5 cm² /m² (women). Cachexia was classified according to the following criteria: involuntary weight loss >5% over the past 6 

SUBMITTER: Shen XD 

PROVIDER: S-EPMC10225236 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature