Nucleoporin 107 is a prognostic biomarker in hepatocellular carcinoma associated with immune infiltration.

ABSTRACT:

Objective

To assess the diagnostic value and clinical significance of nucleoporin 107 (NUP107) in hepatocellular carcinoma (HCC), and explore the possible mechanisms.

Methods

The transcriptomic and clinical data of HCC patients were retrieved from The Cancer Genome Atlas (TCGA) and GEO databases. Tissue specimens were collected from HCC patients in the Guangxi area. According to the expression levels and prognostic characteristics of NUP107, ROC curves and nomogram models were constructed using the R package.

Results

NUP107 was highly expressed in 26 human cancers including HCC, and was associated with advanced HCC staging and worse prognosis. NUP107 showed satisfactory ability to predict the prognosis of HCC patients (AUC >0.8). Results of gene set enrichment analysi

SUBMITTER: Nong JS 

PROVIDER: S-EPMC10225238 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature