Molecular genetic characteristics of thymic epithelial tumors with distinct histological subtypes.

ABSTRACT:

Background

Due to the low incidence and histological heterogeneity, the molecular features and underlying carcinogenic mechanisms of thymic epithelial tumors (TETs) are yet to be fully elucidated, especially for different subtypes of TETs.

Methods

Tumor tissue samples of 43 TETs with distinct histological subtypes were collected. We analyzed the molecular characteristics in different subtypes based on whole exome sequencing data.

Results

The mutational profiles of the different subtypes of TETs varied. Compared with thymomas, thymic carcinomas (TCs) had a higher mutation frequency of MYO16 (33% vs. 3%, p = 0.024) and a lower frequency of ZNF729 mutations (0% vs. 35%, p = 0.044). No significant difference was observed in the median tumor mutation burden across differen

SUBMITTER: Yang J 

PROVIDER: S-EPMC10225241 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature