Impact of age, antiretroviral therapy, and cancer on epigenetic aging in people living with HIV.

ABSTRACT:

Background

Premature aging has been identified as a global risk factor for cancer. Causes of premature aging are multifactorial, including inflammation, infection, chronic stress, and lifestyle factors.

Method

We evaluated whether premature aging in people living with HIV (PLWH) was associated with antiretroviral therapy (ART) or the diagnosis of cancer. We used well-established DNA methylation patterns to assess premature aging, using Horvath et al., in individuals with HIV located in Cleveland, Ohio and compared these to standardized datasets of US historical blood samples. Some of the PLWH developed cancer over time.

Results

We found that DNA methylation analysis identified accelerated aging in PLWH whereas ART therapy mitigated the advancement of DNA methylation a

SUBMITTER: Qing Y 

PROVIDER: S-EPMC10225243 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature