In silico docking based screening of constituents from Persian shallot as modulators of human glucokinase.

ABSTRACT:

Purpose

Small molecule glucokinase (GK) modulators not only decrease fasting and basal plasma sugar contents but also progress glucose tolerance. The hydro-ethanolic extract of the Persian shallot (Allium hirtifolium Boiss.) decreased blood glucose, improved plasma insulin and amplified GK action. The present study was proposed to screen phytoconstituents from Persian shallot as human GK activators using in silico docking studies.

Methods

A total of 91 phytoconstituents reported in Persian shallot (A. hirtifolium Boiss.) were assessed in silico for the prediction of drug-like properties and molecular docking investigations were carried out with human GK using AutoDock vina with the aim of exploring the binding interactions between the phytoconstituents and GK e

SUBMITTER: Kaur A 

PROVIDER: S-EPMC10225407 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature