Association between serum interleukin-6, leptin and insulin in gestational diabetes mellitus - a cross- sectional study.

ABSTRACT:

Purpose

Gestational diabetes mellitus (GDM) is a state of leptin resistance which develops a vicious cycle of hyperinsulinemia and hyperleptinemia leading to aggravation of an inflammatory situation. This study was done to find out the association between IL-6, leptin and insulin in gestational diabetes among North Indian women.

Method

This cross-sectional study included 100 GDM, 100 non-GDM and 50 non-pregnant women. DIPSI (Diabetes in Pregnancy Study Group India) criteria was used for screening GDM among pregnant women. GDM and non-GDM pregnant women were further categorized into three groups according to the trimester of pregnancy. Serum IL-6, leptin and insulin were measured in all the enrolled women.

Results

Serum IL-6 levels were significantly higher amon

SUBMITTER: Srivastava N 

PROVIDER: S-EPMC10225451 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature