Effects of tadalafil on sexual behavior of male rats induced by chronic unpredictable mild stress

ABSTRACT: Abstract

Background

Few studies have investigated psychogenic sexual dysfunction including psychogenic erectile dysfunction (pED); the effect of tadalafil on sexual behavior of male rats induced by chronic unpredictable mild stress (CUMS) remains unclear.

Aim

The aim was to explore the influence of CUMS on sexual behavior of male rats and the effects of tadalafil on that.

Methods

Adult male rats were divided into 3 groups, including the normal group without CUMS, the model group with 6 weeks’ CUMS, and the tadalafil group with treatment of tadalafil during CUMS. CUMS consists of water deprivation, food deprivation, stroboscopic lightning, white noise, cage tilting, weeding packing, and housing 2 unfamiliar rats. The apomorphine test and vaginal smear test were co

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PROVIDER: S-EPMC10225468 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature