Applying CRISPR-Cas9 screens to dissect hematological malignancies.

ABSTRACT: Bit by bit, over the last few decades, functional genomic tools have been piecing together the molecular puzzle driving tumorigenesis in human patients. Nevertheless, our understanding of the role of several genes and regulatory elements that drive critical cancer-associated physiological processes from disease development to progression to spread is very limited, which significantly affects our ability of applying these insights in the context of improved disease management. The recent advent of clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9)-based technology and its application in cancer genomics has, however, allowed the generation of a wealth of knowledge that has helped decipher several critical questions associated with translatio

SUBMITTER: Iyer DN 

PROVIDER: S-EPMC10225491 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature