Prediction of risk and overall survival of pancreatic cancer from blood soluble immune checkpoint-related proteins.

ABSTRACT:

Background

Immune checkpoint inhibition holds promise as a novel treatment for pancreatic ductal adenocarcinoma (PDAC). The clinical significance of soluble immune checkpoint (ICK) related proteins have not yet fully explored in PDAC.

Methods

We comprehensively profiled 14 soluble ICK-related proteins in plasma in 70 PDAC patients and 70 matched healthy controls. Epidemiological data of all subjects were obtained through structured interviews, and patients' clinical data were retrieved from electronical health records. We evaluated the associations between the biomarkers with the risk of PDAC using unconditional multivariate logistic regression. Consensus clustering (k-means algorithm) with significant biomarkers was performed to identify immune subtypes in PDAC patients. Pr

SUBMITTER: Pan S 

PROVIDER: S-EPMC10225568 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature