The fusiform gyrus exhibits differential gene-gene co-expression in Alzheimer's disease.

ABSTRACT: Alzheimer's Disease (AD) is an irreversible neurodegenerative disease clinically characterized by the presence of β-amyloid plaques and tau deposits in various regions of the brain. However, the underlying factors that contribute to the development of AD remain unclear. Recently, the fusiform gyrus has been identified as a critical brain region associated with mild cognitive impairment, which may increase the risk of AD development. In our study, we performed gene co-expression and differential co-expression network analyses, as well as gene-expression-based prediction, using RNA-seq transcriptome data from post-mortem fusiform gyrus tissue samples collected from both cognitively healthy individuals and those with AD. We accessed differential co-expression networks in large cohorts such as

SUBMITTER: Ribeiro-Dos-Santos A 

PROVIDER: S-EPMC10225579 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature