Effectiveness of early heparin therapy on outcomes in critically ill patients with sepsis-induced coagulopathy.

ABSTRACT: Background: This study aimed to investigate whether early unfractionated heparin (UFH) administration provides a survival advantage for patients with sepsis-induced coagulopathy (SIC). Methods: Patients hospitalized with sepsis-induced coagulopathy from the Medical Information Mart for Intensive Care (MIMIC)-IV database were identified. Patients were divided into two groups, who received unfractionated heparin (UFH) subcutaneously within 24 h after intensive care unit (ICU) admission, and the control group, who received not. The primary endpoint was intensive care unit mortality, the secondary outcomes were 7, 14, and 28-day and hospital mortality. Propensity score matching (PSM) the marginal structural Cox model (MSCM) and E-value analysis were used to account for baseline d

SUBMITTER: Huang JJ 

PROVIDER: S-EPMC10225678 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature