Developmentally regulated expression of integrin alpha-6 distinguishes neural crest derivatives in the skin.

ABSTRACT: Neural crest-derived cells play essential roles in skin function and homeostasis. However, how they interact with environmental cues and differentiate into functional skin cells remains unclear. Using a combination of single-cell data analysis, neural crest lineage tracing, and flow cytometry, we found that the expression of integrin α6 (ITGA6) in neural crest and its derivatives was developmentally regulated and that ITGA6 could serve as a functional surface marker for distinguishing neural crest derivatives in the skin. Based on the expression of ITGA6, Wnt1-Cre lineage neural crest derivatives in the skin could be categorized into three subpopulations, namely, ITGA6^bright, ITGA6^dim, and ITGA6^neg, which were found to be Schwann cells, melanocytes, and fib

SUBMITTER: Ma S 

PROVIDER: S-EPMC10225710 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature