Fecal microbiota transplant delivered via invasive routes in irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background and aims

Irritable bowel syndrome (IBS) results in significant loss of quality of life. Management guidelines do not recommend fecal microbiota transplant (FMT) for IBS based on weak evidence as refined data is lacking. We performed a systematic review and meta-analysis to ascertain the pooled clinical outcomes of FMT in IBS, delivered via invasive routes.

Methods

Multiple databases were searched through January 2023 to identify studies that reported on FMT treatment in IBS by invasive routes. Standard meta-analysis methodology using the random-effects model was used. Heterogeneity was assessed by I²% and 95% predication interval.

Results

Five studies were included. As many as 377 IBS patients were assessed, of which 238 received FMT and 139 rece

SUBMITTER: Mohan BP 

PROVIDER: S-EPMC10225764 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature