The vertebrate sialylation machinery: structure-function and molecular evolution of GT-29 sialyltransferases.

ABSTRACT: Every eukaryotic cell is covered with a thick layer of complex carbohydrates with essential roles in their social life. In Deuterostoma, sialic acids present at the outermost positions of glycans of glycoconjugates are known to be key players in cellular interactions including host-pathogen interactions. Their negative charge and hydrophilic properties enable their roles in various normal and pathological states and their expression is altered in many diseases including cancers. Sialylation of glycoproteins and glycolipids is orchestrated by the regulated expression of twenty sialyltransferases in human tissues with distinct enzymatic characteristics and preferences for substrates and linkages formed. However, still very little is known on the functional organization of sialyltransferases

SUBMITTER: Harduin-Lepers A 

PROVIDER: S-EPMC10225777 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature