Glycerol as a precursor for hepatic de novo glutathione synthesis in human liver.

ABSTRACT:

Background

Glycerol is a substrate for gluconeogenesis and fatty acid esterification in the liver, processes which are upregulated in obesity and may contribute to excess fat accumulation. Glycine and glutamate, in addition to cysteine, are components of glutathione, the major antioxidant in the liver. In principle, glycerol could be incorporated into glutathione via the TCA cycle or 3-phosphoglycerate, but it is unknown whether glycerol contributes to hepatic de novo glutathione biosynthesis.

Methods

Glycerol metabolism to hepatic metabolic products including glutathione was examined in the liver from adolescents undergoing bariatric surgery. Participants received oral [U-¹³C₃]glycerol (50 mg/kg) prior to surgery and liver tissue (0.2-0.7g) was obtaine

SUBMITTER: Jin ES 

PROVIDER: S-EPMC10225920 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature