Targeting copper death genotyping associated gene RARRES2 suppresses glioblastoma progression and macrophages infiltration.

ABSTRACT:

Background

Copper homeostasis is associated with malignant biological behavior in various tumors. The excessive accumulation of copper can induce tumor death, which is named cuproptosis, and it is also closely related to tumor progression and the formation of the immune microenvironment. However, the associations of cuproptosis with glioblastoma (GBM) prognosis and microenvironment construction are poorly understood.

Method

First, TCGA and GEO (GSE83300, GSE74187) merged datasets were used to analyze the association of cuproptosis-related genes (CRGs) with GBM. Then, we performed cluster analysis of CRGs in GBM from the GEO (GSE83300, GSE74187) and TCGA merged datasets. Subsequently, the prognostic risk model was constructed by least absolute shrinkage and selection operator

SUBMITTER: Yan T 

PROVIDER: S-EPMC10226210 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature