Anti-inflammatory effect of Irisin on LPS-stimulated macrophages through inhibition of MAPK pathway.

ABSTRACT: This study aimed to investigate the effect of irisin on LPS-induced inflammation in RAW 264.7 macrophages through inhibition of the mitogen-activated protein kinase (MAPK) pathway. A network pharmacology-based approach, combined with molecular docking and in vitro validation were performed to identify the biological activity, key targets, and potential pharmacological mechanisms of irisin against LPS-induced inflammation. By matching 100 potential genes of irisin with 1893 ulcerative colitis (UC) related genes, 51 common genes were obtained. Using protein-protein interaction networks (PPI) and component-target network analysis,10 core genes of irisin on UC were further identified. The results of gene ontology (GO) enrichment analysis showed that the molecular mechanisms of irisin on UC wer

SUBMITTER: Ma Y 

PROVIDER: S-EPMC10226406 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature