Liver proteomic analysis reveals the key proteins involved in host immune response to sepsis

ABSTRACT:

Background

Sepsis is a serious infection-induced response in the host, which can result in life-threatening organ dysfunction. It is of great importance to unravel the relationship between sepsis and host immune response and its mechanisms of action. Liver is one of the most vulnerable organs in sepsis, however, the specific pathogenesis of septic liver injury has not been well understood at the protein level.

Methods

A total of 12 healthy Sprague–Dawley (SD) male rats aged from 6 to 8 weeks were adaptively housed in individual cages in the specific pathogen free animal room. These lab rats were grouped into two groups: treatment (N = 9) and control (N = 3) groups; only three mice from the treatment group survived and were used for subsequent experiments. A TMT-based prot

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10226476 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature