LC-MS based urine untargeted metabolomic analyses to identify and subdivide urothelial cancer

ABSTRACT:

Introduction

Urine metabolomics has been a promising technique in the liquid biopsy of urothelial cancer (UC). The comparison of upper tract urothelial cancer (UTUC), lower tract urothelial cancer (BCa), and healthy controls (HCs) need to be performed to find related biomarkers.

Methods

In our investigation, urine samples from 35 UTUCs, 44 BCas, and 53 gender- and age-matched HCs were analyzed using liquid chromatography-high resolution mass spectrometry (LC-HRMS). In different groups, the differential metabolites and the disturbed metabolism pathways were explored. Transcriptomics and urine metabolomics are combined to identify the probably disturbed gene in BCa.

Results

With an area under the curve (AUC) of 0.815, the panel consisting of prostaglandin I2, 5-met

SUBMITTER: Yang M 

PROVIDER: S-EPMC10226587 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature