Association between MetS-IR and prediabetes risk and sex differences: a cohort study based on the Chinese population.

ABSTRACT:

Objective

The metabolic score for insulin resistance (MetS-IR) is an emerging surrogate marker for insulin resistance (IR). This study aimed to investigate the association and sex differences between MetS-IR and prediabetes risk in a Chinese population.

Methods

This cohort study included 100,309 adults with normoglycemia at baseline and had followed longitudinally for 5 years, and with prediabetes, defined according to the 2018 American Diabetes Association (ADA) recommended diagnostic criteria, as the outcome of interest. Multivariate Cox proportional hazards regression and restricted cubic spline (RCS) regression models were used to assess the association between MetS-IR and prediabetes risk.

Results

During an observation period of 312,843 person-years, 7,735 (14.84

SUBMITTER: Xie Q 

PROVIDER: S-EPMC10226663 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature