Deprescribing to optimise health outcomes for frail older people: a double-blind placebo-controlled randomised controlled trial—outcomes of the Opti-med study

ABSTRACT: Abstract

Background

potentially harmful polypharmacy is very common in older people living in aged care facilities. To date, there have been no double-blind randomised controlled studies of deprescribing multiple medications.

Methods

three-arm (open intervention, blinded intervention and blinded control) randomised controlled trial enrolling people aged over 65 years (n = 303, noting pre-specified recruitment target of n = 954) living in residential aged care facilities. The blinded groups had medications targeted for deprescribing encapsulated while the medicines were deprescribed (blind intervention) or continued (blind control). A third open intervention arm had unblinded deprescribing of targeted medications.

Results

participants were 76% female with mean age

SUBMITTER:  

PROVIDER: S-EPMC10226731 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature