Softness enhanced macrophage-mediated therapy of inhaled apoptotic-cell-inspired nanosystems for acute lung injury.

ABSTRACT: Engineered nanosystems offer a promising strategy for macrophage-targeted therapies for various diseases, and their physicochemical parameters including surface-active ligands, size and shape are widely investigated for improving their therapeutic efficacy. However, little is known about the synergistic effect of elasticity and surface-active ligands. Here, two kinds of anti-inflammatory N-acetylcysteine (NAC)-loaded macrophage-targeting apoptotic-cell-inspired phosphatidylserine (PS)-containing nano-liposomes (PSLipos) were constructed, which had similar size and morphology but different Young's modulus (E) (H, ~ 100 kPa > E_macrophage vs. L, ~ 2 kPa < E_macrophage). Interestingly, these PSLipos-NAC showed similar drug loading and encapsulation efficiency, and in vitro

SUBMITTER: Sun D 

PROVIDER: S-EPMC10226883 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature