Evidence against a temporal association between cerebrovascular disease and Alzheimer's disease imaging biomarkers.

ABSTRACT: Whether a relationship exists between cerebrovascular disease and Alzheimer's disease has been a source of controversy. Evaluation of the temporal progression of imaging biomarkers of these disease processes may inform mechanistic associations. We investigate the relationship of disease trajectories of cerebrovascular disease (white matter hyperintensity, WMH, and fractional anisotropy, FA) and Alzheimer's disease (amyloid and tau PET) biomarkers in 2406 Mayo Clinic Study of Aging and Mayo Alzheimer's Disease Research Center participants using accelerated failure time models. The model assumes a common pattern of progression for each biomarker that is shifted earlier or later in time for each individual and represented by a per participant age adjustment. An individual's amyloid and tau PE

SUBMITTER: Cogswell PM 

PROVIDER: S-EPMC10226977 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature