Removing the association of random gene sets and survival time in cancers with positive random bias using fixed-point gene set.

ABSTRACT: Cancer research aims to identify genes that cause or control disease progression. Although a wide range of gene sets have been published, they are usually in poor agreement with one another. Furthermore, recent findings from a gene-expression cohort of different cancer types, known as positive random bias, showed that sets of genes chosen randomly are significantly associated with survival time much higher than expected. In this study, we propose a method based on Brouwer's fixed-point theorem that employs significantly survival-associated random gene sets and reveals a small fixed-point gene set for cancers with a positive random bias property. These sets significantly correspond to cancer-related pathways with biological relevance for the progression and metastasis of the cancer types th

SUBMITTER: Maghsoudi M 

PROVIDER: S-EPMC10226989 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature