Boosting intracellular sodium selectively kills hepatocarcinoma cells and induces hepatocellular carcinoma tumor shrinkage in mice.

ABSTRACT: Pharmacological treatments for advanced hepatocellular carcinoma (HCC) have a partial efficacy. Augmented Na⁺ content and water retention are observed in human cancers and offer unexplored targets for anticancer therapies. Na⁺ levels are evaluated upon treatments with the antibiotic cation ionophore Monensin by fluorimetry, ICP-MS, ²³Na-MRI, NMR relaxometry, confocal or time-lapse analysis related to energy production, water fluxes and cell death, employing both murine and human HCC cell lines, primary murine hepatocytes, or HCC allografts in NSG mice. Na⁺ levels of HCC cells and tissue are 8-10 times higher than that of healthy hepatocytes and livers. Monensin further increases Na⁺ levels in HCC cells and in HCC allografts but not in

SUBMITTER: Clemente N 

PROVIDER: S-EPMC10227045 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature