Real-world evidence for steroidal mineralocorticoid receptor antagonists in patients with chronic kidney disease.

ABSTRACT:

Background

Mineralocorticoid receptor antagonists (MRAs) were shown to delay chronic kidney disease (CKD) progression in patients with hypertension and/or heart failure (HF) and proteinuria.

Objective

We conducted a systematic literature review on real-world evidence to identify the literature gaps related to the efficacy and safety outcomes of MRAs administered to CKD patients.

Results

A total of 751 records were identified of which, 23 studies (26 publications) were analyzed. Studies included heterogeneous populations, including the overall CKD, CKD and diabetes, CKD and HF, and CKD and a history of cardiovascular disease. Most of the studies were small and non-rigorous, resulting in a notable lack of evidence in these populations. In the overall CKD population, ste

SUBMITTER: Folkerts K 

PROVIDER: S-EPMC10227157 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature