Extrafollicular IgD^-CD27^-CXCR5^-CD11c^- DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19.

ABSTRACT: Although therapeutic B cell depletion dramatically resolves inflammation in many diseases in which antibodies appear not to play a central role, distinct extrafollicular pathogenic B cell subsets that accumulate in disease lesions have hitherto not been identified. The circulating immunoglobulin D (IgD)^-CD27^-CXCR5^-CD11c⁺ DN2 B cell subset has been previously studied in some autoimmune diseases. A distinct IgD^-CD27^-CXCR5^-CD11c^- DN3 B cell subset accumulates in the blood both in IgG4-related disease, an autoimmune disease in which inflammation and fibrosis can be reversed by B cell depletion, and in severe COVID-19. These DN3 B cells prominently accumulate in the end organs of IgG4-related disease and in

SUBMITTER: Allard-Chamard H 

PROVIDER: S-EPMC10227203 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature